Helicobacter pylori arginase mutant colonizes arginase II knockout mice

Apoptosis by Activation of Arginase II Induces Macrophage Helicobacter pylori

Polyamine homeostasis in arginase knockout mice.

The role of ornithine decarboxylase (ODC) in polyamine metabolism has long been established, but the exact source of ornithine has always been unclear. The arginase enzymes are capable of producing ornithine for the production of polyamines and may hold important regulatory functions in the maintenance of this pathway. Utilizing our unique set of arginase single and double knockout mice, we ana...

Arginase-II Deficiency Extends Lifespan in Mice

The mitochondrial arginase type II (Arg-II) has been shown to interact with ribosomal protein S6 kinase 1 (S6K1) and mitochondrial p66Shc and to promote cell senescence, apoptosis and inflammation under pathological conditions. However, the impact of Arg-II on organismal lifespan is not known. In this study, we demonstrate a significant lifespan extension in mice with Arg-II gene deficiency (Ar...

Nitric Oxide Synthase Translation in by Attenuating Inducible Helicobacter pylori Arginase II Restricts Host Defense to

Immune evasion by Helicobacter pylori is mediated by induction of macrophage arginase II.

Helicobacter pylori infection persists for the life of the host due to the failure of the immune response to eradicate the bacterium. Determining how H. pylori escapes the immune response in its gastric niche is clinically important. We have demonstrated in vitro that macrophage NO production can kill H. pylori, but induction of macrophage arginase II (Arg2) inhibits inducible NO synthase (iNOS...